By Jenxoxo Added at December 9, 2010 Views 5,153 Reviews 5

Plavix can cure migraines in some sufferers. I know. I'm one of them.

Quick background: I had heart surgery last year to fix a large hole (PFO) that has been known to cause migraines, although it didn't fix mine. While on Plavix, a blood thinner, I had no migraines. After stopping Plavix, my migraines returned. Back on Plavix, no migraines.

Here's the deal according to my heart surgeon (in much simpler terms): My platelets in my blood are very sticky and/or I have more than usual. When they are sticky, they can form mini-clots in the brain causing migraines or even strokes. The Plavix I am taking is bringing my blood to normal ranges by making my platelets slippery.

I read a few research papers and websites that verified this. When tested, the platelets in migraine sufferers are different from normal platelets during and in between attacks. There is a significant increase in spontaneous clumping of the platelets for people with migraines.

There is a doctor in the UK that is conducting a clinical trial for Plavix on migraine patients. Dr. John Chambers' theory is that small clots are what cause the migraines in a segment of migraine sufferers.

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Reviews (5 reviews)

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Juniorsmom June 2, 2014 at 1:06 pm   

I have to agree 100%, had my PFO closed a year ago this month and my migraines have been horible, I'm trying now to get back on the Plavix, just had tests last week because they think I had a blood clot (positive D-Dimer test), even if there is a chance I can feel a little bit better I'll risk taking the Plavix since nothing I have done in 20 years has worked!

Lois T
Lois T December 19, 2012 at 2:36 pm   

That is really interesting. I used to be on Plavix for years and do not remember having a problem with migraines. Lately I have been. I am no longer on a blood thinner. Thank you for this information.

Jenxoxo October 27, 2011 at 9:12 pm   

I read that also, but all my doctors disagree. I'm not sure how accurate the info on the web is. Still, you should consider everything.

mosweeny August 26, 2011 at 7:37 am   

sounds amazing. worth a try anyway. what i read about plavix is that it's pretty full-on… have to be on it the rest of your life or a heart attack is possible.
any side effects for you?
thanks so much for sharing.

Jenxoxo December 9, 2010 at 9:09 pm   

If it works for you, no more migraines.


There are risks while using Plavix. Ask your doctor.